Study Region: Our study region is the Baltic Sea Drainage Basin (BSDB), which covers an area of 1.8 Mio km2 distributed over 14 countries in northern Europe.Study Focus: We use a large-scale hydrological and nutrient transport model (E-HYPE) to model basin-wide impacts of measure scenarios on the Baltic Sea, where eutrophication is a critical issue
Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells.However, CRISPR-based HIV excision is vulnerable to viral escape.Targeting cellular co-factors provides an attractive yet risky alternative to render viral escape irrelevant.Cyclin T1 is a
BACKGROUND: In several neurodegenerative diseases, hyperphosphorylation at position Ser129 is found in fibrillar deposits of alpha-synuclein (asyn), implying a pathophysiological role of asyn phosphorylation in neurodegeneration.However, recent animal models applying asyn phosphorylation mimics demonstrated a protective effect of phosphorylation.Si